PsoriasisIt is a systemic disease characterized by damage to the skin, the musculoskeletal system, functional and morphological disorders of other organs and systems. The main symptoms of pathology: nodular rashes on the scalp, palms, feet, extensor surfaces of the elbows and knees, hyperemia, itching. The disease can be diagnosed visually, but to exclude the possibility of developing concomitant pathologies, laboratory tests and instrumental diagnostic methods are prescribed. Systemic therapy includes taking aromatic retinoids and cytostatic drugs, glucocorticosteroids.
Introduction
The name of the disease comes from the Greek "psora" - "skin disease", "scab". In the Middle Ages, psoriasis was considered a form of leprosy (leprosy). The signs of psoriasis were first described from a professional point of view in 1808 by Robert Whelan in Great Britain. The term "psoriasis" was coined by the Viennese dermatologist Ferdinand Gebra in 1841. The pathology is recorded in all latitudes of the world with an uneven frequency of 0. 1 to 3%. Psoriasis develops equally in men and women, but among children it is more common in girls and among adults - in men (60-65%).
Causes
There are several theories about the origin of psoriasis. The main ones are parasitic, infectious, allergic, infectious-allergic, autoimmune, neurogenic, endocrine, hereditary. Each of these theories is based on clinical observations and laboratory results.
Most scientists pay attention to the genetic nature of psoriasis. They claim that this disease is of polygenic inheritance. If one of the parents is sick, the risk of the child developing pathology is 8%, if the father and mother are 41%.
The factors that contribute to the development of psoriasis are divided into external and internal.
- External factors include mechanical and chemical damage to the skin, as well as dermatoses.
- Doctors include internal provoking factors: infections (streptococci and human immunodeficiency viruses), medications (corticosteroids, non-steroidal anti-inflammatory drugs), nervous stress.
Pathogenesis
Today, doctors around the world recognize the involvement of the immune system in the pathogenesis of psoriasis. Cells of the immune system, which normally react to antigens, begin to attack healthy cells, most often skin cells. As a result of this process, the cells of the epidermal layer divide faster than usual. They do not have time to mature, so strong bonds are not established between them. The cells, rising to the surface, form protruding plates with silvery scales.
Classification
According to the International Statistical Classification of Diseases and Related Health Problems, there are many types of psoriasis.
- Ordinary (vulgar). The most common form of lichen planus, in which there are no complications. This group includes plaque and coin psoriasis.
- Generalized pustular psoriasis- a severe form of pathology, complicated by secondary infection. It affects several areas at the same time. Includes Zumbusch syndrome and impetigo herpetiformis.
- Persistent acrodermatitis (Crocker dermatitis, Setton dermatitis)— the contents of the pustules are sterile, there is no secondary infection. The main affected areas are the fingers and nails.
- Palmar and plantar pustulosis (bacterida pustulosa)- develops on the feet and palms. It appears as pustules with sterile contents, which gradually increase in area.
- teardrop shaped- separately located papules that do not merge into plaques. The most commonly affected areas are the legs, thighs, back, forearms, chest and neck.
- arthropathic- the clinical course resembles the rheumatic form of arthritis.
- Other psoriasis (reverse)- The conglomerates are located in the armpits, inguinal and other natural folds. This type includes flexor inverse psoriasis.
- Unspecified psoriasis- combines several types of pathology, the clinical picture is quite broad.
Depending on the seasonality of the exacerbation, several types of psoriasis are distinguished:
- summer- exacerbation occurs as a result of exposure of the skin to sunlight;
- winter- occurs due to extreme cold that affects the skin.
In non-seasonal psoriasis there are no periods of remission, the disease occurs throughout the year.
By affected skin area:
- limited psoriasis- occupies less than 20% of the body's skin;
- common- more than 20%;
- widespread- all skin is affected.
Symptoms
The clinical manifestations of psoriasis depend directly on the stage of development of the disease. There are 3 stages.
- progressive stage. It is characterized by the appearance of papules, itching, the appearance of peeling, peeling and deformation of the nails.
- stationary stage. No new papules appear, the previous rash does not increase in size, and the peeling is moderate.
- Regressive stage. The plaques heal and in their place depigmented white spots form that no longer cause discomfort.
Skin rashes are only external signs of psoriasis. In fact, the disease affects numerous organs and systems, in addition to tendons and joints. For this reason, patients complain of depression, a constant feeling of weakness and chronic fatigue.
Complications
Among the complications of psoriasis, psoriatic arthritis and psoriatic erythroderma are especially important. In addition, in the absence of timely diagnosis and effective treatment of psoriasis, the risk of developing serious chronic pathologies increases: diabetes mellitus, high blood pressure and metabolic syndrome.
Diagnosis
To identify pathology, instrumental and laboratory diagnostic methods are used.
The patient receives a referral to:
- general clinical analysis of blood and urine;
- blood biochemistry;
- blood tests for C-reactive protein and rheumatic tests;
- coagulogram: evaluation of blood coagulation;
- blood test to detect human leukocyte antigen.
For complicated forms of psoriasis, which are associated with damage to the musculoskeletal system and internal organs, x-rays of the joints, ultrasound of the kidneys and organs of the urinary system, and echocardiography are prescribed.
There are diseases that have similar symptoms. As a result, there is a need for differential diagnosis. To do this, use methods like:
- biopsy (excision of a piece of skin with additional histological examination);
- Laboratory tests: used to distinguish psoriasis from papular syphilid.
Treatment
Psoriasis responds well to symptomatic treatment. Knowing the pathogenesis, the doctor can individually select a treatment method. Some of them are aimed at reducing skin rashes, eliminating dryness and itching, others - preventing the immune system from "attacking" healthy cells.
Therapeutic tactics directly depend on the severity of the disease and the location of the lesions.
External therapy
Topical glucocorticosteroids are used for various forms of psoriasis as monotherapy or in combination with other drugs. They exist in the form of pharmaceutical forms: ointments, creams or lotions.
Medicines containing vitamin D3 analogues. They are applied to the affected areas of the skin if the prevalence of psoriasis does not exceed 30% of the body surface.
Preparations containing activated zinc pyrithione are used in the form of a spray, cream and also scalp shampoo.
Phototherapy
For treatment in this case, the methods of medium wave phototherapy and PUVA therapy are used. PUVA therapy is the combined use of long-wave ultraviolet (UVA) rays (320-400 nm) and a photosensitizer (8-methoxypsoralen). PUVA therapy is one of the most effective ways to cure the disease; It is most often prescribed for generalized vulgar and exudative psoriasis, persistent pathology and severe infiltration.
Combination therapy
Said treatment includes several therapeutic modalities, for example: phototherapy and topical corticosteroids; phototherapy and systemic retinoids.
Systemic therapy
Prescribed for moderate and severe forms of psoriasis. Systemic therapy drugs are mainly prescribed during disease progression.
Biological drugs
These medications are created using genetic engineering methods. They are monoclonal antibodies and are used for therapeutic purposes.
Prognosis and prevention
With timely diagnosis of the pathology and effective treatment, the prognosis is quite favorable. As preventive measures, the following are often prescribed: a diet enriched with fish and vegetables, hydrotherapy, a course of phytotherapy, treatment in a sanatorium and emollients (mainly in the period between relapses, to restore the hydrolipid layer).